I've been using Vectra 3D for years with no problems, but when I put it on Polar this month, he seemed to be irritated/burned by it. Anyone else use it? Do you think it's safe?

I've read some pretty bad things about it, but I have also heard things about front line and other topical flea products. I'm putting London on Trifexis when she turns 8 weeks I'll let you know how it goes. Found this on a search about it might explain what happened to your pup..
"I spoke to the manufacturer this morning (we were out of town after we applied the product so had to wait to follow up) and she explained that Vectra 3D (sorry about the typo first time) doesn't absorb into the dog's body, it dries & stays on their skin for the 30 days. I had no idea, I think the Vet should explain that to people. She said some dogs are more sensitive to the sensation of it spreading on their skin & don't react well to it. I don't think that matches with the reaction we were seeing, I'd say it was more like the product was burning his skin & he was experiencing pain & was pretty upset about it. "

Vectra is what my vet tried selling to me for Evie, then I went home and researched it. Way too many horror stories out there so I went with Frontline.

I don't use topicals. I keep comfortis on hand (literally in my purse) and use it if needed. Cato gets a dose when he goes to a show. Delilah hasn't been treated aside from diatomaceous earth and oils.

I don't like chemicals